Selected Publications

Alcedo, J., and Prahlad, V. (2020). Neuromodulators: an essential part of survival. J Neurogenet 34, 475-481. doi: 10.1080/01677063.2020.1839066.

Wu, T., Duan, F., Yang, W., Liu, H., Caballero, A., Fernandes de Abreu, D.A., Dar, A.R., Alcedo, J., Ch’ng, Q.L., Butcher, R.A., and Zhang, Y. (2019). Pheromones modulate learning by regulating the balanced signals of two insulin-like peptides. Neuron 104, 1095-1109.

Ewald, C.Y., Hourihan, J.M., Bland, M.S., Obieglo, C., Katic, I., Moronetti Mazzeo, L.E., Alcedo, J., Blackwell, T.K., and Hynes, N.E. (2017). NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. eLife 6, e19493.

Artan, M., Jeong, D.E., Lee, D., Kim, Y.I., Son, H.G., Husain, Z., Kim, J., Altintas, O., Kim, K., Alcedo, J., and Lee, S.J. (2016). Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. Genes Dev 30, 1047-1057.

Allen, E.N., Ren, J., Zhang, Y., and Alcedo, J. (2015). Sensory systems: their impact on C. elegans survival. Neuroscience, 296, 15-25.

Ostojic, I., Boll, W., Waterson, M.J., Chan, T., Chandra, R., Pletcher, S.D., and Alcedo, J. (2014). Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signalingProc Natl Acad Sci USA 111, 8143-8148.

Waterson, M.J., Chung, B.Y., Harvanek, Z.M., Ostojic, I., Alcedo, J., and Pletcher, S.D. (2014). Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signalingProc Natl Acad Sci USA 111, 8137-8142.

Fernandes de Abreu, D.A.*, Caballero, A.*, Fardel, P., Stroustrup, N., Chen, Z., Lee, K., Keyes, W.D., Nash, Z.M., López-Moyado, I.F., Vaggi, F., Cornils, A., Regenass, M., Neagu, A, Ostojic, I., Liu, C., Cho, Y., Sifoglu, D., Shen, Y., Fontana, W., Lu, H., Csikasz-Nagy, A., Murphy, C.T., Antebi, A. +, Blanc, E. +, Apfeld, J. +, Zhang, Y. +, Alcedo, J. +, and Ch’ng, Q. + (2014). An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet 10, e1004225. (*:Equal contributions; +:Co-corresponding authors)


Alcedo, J., Flatt, T., and Pasyukova, E. (2013). Neuronal inputs and outputs of aging and longevity . Front Genet 4, 71. doi: 10.3389/fgene.2013.00071. 

Chen, Z., Hendricks, M., Cornils, A., Maier, W., Alcedo, J., and Zhang, Y. (2013). Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans. Neuron 77, 572–585.

​Alcedo, J., and Zhang, Y. (2013). Molecular and cellular circuits underlying C. elegans olfactory plasticity. In: Menzel R and Benjamin PR (eds), Invertebrate Learning and Memory. Elsevier/Academic Press, San Diego, CA, pp. 112-123.

Cornils, A., Gloeck, M., Chen, Z., Zhang, Y., and Alcedo, J. (2011). Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Development, 138, 1183-1193.


Fierro-Gonzalez, J. C., Cornils, A., Alcedo, J., Vizuete, A. M., and Swoboda, P. (2011). The thioredoxin TRX-1 modulates the function of an insulin-like neuropeptide during dauer formation in Caenorhabditis elegans. PLoS One 6, e16561.​

Maier, W.*, Adilov, B.*, Regenass, M., and Alcedo, J. (2010). A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol 8, e1000376. (*These authors contributed
equally to this work.)

Alcedo, J., Maier, W., and Ch’ng, Q. (2010). Sensory influence on homeostasis and lifespan: molecules and circuits. Tavernarakis N (ed), Protein Metabolism and Homeostasis in Aging. Landes Bioscience, Austin, TX, pp. 197-210.

Noll, H., Alcedo, J., Frei, E., Hunt, J., Matranga, V., Hochstrasser, M., Aebersold, R., Newitt, R., and Noll, M. (2007). The major cell adhesion glycoprotein of the sea urchin embryo is an ironless, calcium-binding member of the transferrin family. Dev. Biol. 310, 54-70.

Alcedo, J., and Kenyon, C. (2004). Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41, 45-55. (Cover; Featured and previewed article)

Alcedo, J.*, Zou, Y.*, and Noll, M. (2000). Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol. Cell  6, 457-465. (*These authors contributed equally to this work.)

Alcedo, J., and Noll, M.  (1997). Hedgehog and its Patched-Smoothened receptor complex: a novel signalling mechanism at the cell surface. Biol. Chem.  378, 583-590. (Review; Cover)


​Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M., and Hooper, J. E.  (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell  86, 221-232.

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