Selected Publications

Wu, T., Duan, F., Yang, W., Liu, H., Caballero, A., Fernandes de Abreu, D.A., Dar, A.R., Alcedo, J., Ch’ng, Q.L., Butcher, R.A., and Zhang, Y. (2019). Pheromones modulate learning by regulating the balanced signals of two insulin-like peptides. Neuron 104, 1095-1109.

Ewald, C.Y., Hourihan, J.M., Bland, M.S., Obieglo, C., Katic, I., Moronetti Mazzeo, L.E., Alcedo, J., Blackwell, T.K., and Hynes, N.E. (2017). NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. eLife 6, e19493.

Artan, M., Jeong, D.E., Lee, D., Kim, Y.I., Son, H.G., Husain, Z., Kim, J., Altintas, O., Kim, K., Alcedo, J., and Lee, S.J. (2016). Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. Genes Dev 30, 1047-1057.

Allen, E.N., Ren, J., Zhang, Y., and Alcedo, J. (2015). Sensory systems: their impact on C. elegans survival. Neuroscience, 296, 15-25.

Ostojic, I., Boll, W., Waterson, M.J., Chan, T., Chandra, R., Pletcher, S.D., and Alcedo, J. (2014). Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signalingProc Natl Acad Sci USA 111, 8143-8148.

Waterson, M.J., Chung, B.Y., Harvanek, Z.M., Ostojic, I., Alcedo, J., and Pletcher, S.D. (2014). Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signalingProc Natl Acad Sci USA 111, 8137-8142.

Fernandes de Abreu, D.A.*, Caballero, A.*, Fardel, P., Stroustrup, N., Chen, Z., Lee, K., Keyes, W.D., Nash, Z.M., López-Moyado, I.F., Vaggi, F., Cornils, A., Regenass, M., Neagu, A, Ostojic, I., Liu, C., Cho, Y., Sifoglu, D., Shen, Y., Fontana, W., Lu, H., Csikasz-Nagy, A., Murphy, C.T., Antebi, A. +, Blanc, E. +, Apfeld, J. +, Zhang, Y. +, Alcedo, J. +, and Ch’ng, Q. + (2014). An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet 10, e1004225. (*:Equal contributions; +:Co-corresponding authors)


Alcedo, J., Flatt, T., and Pasyukova, E. (2013). Neuronal inputs and outputs of aging and longevity . Front Genet 4, 71. doi: 10.3389/fgene.2013.00071. 

Chen, Z., Hendricks, M., Cornils, A., Maier, W., Alcedo, J., and Zhang, Y. (2013). Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans. Neuron 77, 572–585.

​Alcedo, J., and Zhang, Y. (2013). Molecular and cellular circuits underlying C. elegans olfactory plasticity. In: Menzel R and Benjamin PR (eds), Invertebrate Learning and Memory. Elsevier/Academic Press, San Diego, CA, pp. 112-123.

Cornils, A., Gloeck, M., Chen, Z., Zhang, Y., and Alcedo, J. (2011). Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Development, 138, 1183-1193.


Fierro-Gonzalez, J. C., Cornils, A., Alcedo, J., Vizuete, A. M., and Swoboda, P. (2011). The thioredoxin TRX-1 modulates the function of an insulin-like neuropeptide during dauer formation in Caenorhabditis elegans. PLoS One 6, e16561.​

Maier, W.*, Adilov, B.*, Regenass, M., and Alcedo, J. (2010). A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol 8, e1000376. (*These authors contributed
equally to this work.)

Alcedo, J., Maier, W., and Ch’ng, Q. (2010). Sensory influence on homeostasis and lifespan: molecules and circuits. Tavernarakis N (ed), Protein Metabolism and Homeostasis in Aging. Landes Bioscience, Austin, TX, pp. 197-210.

Noll, H., Alcedo, J., Frei, E., Hunt, J., Matranga, V., Hochstrasser, M., Aebersold, R., Newitt, R., and Noll, M. (2007). The major cell adhesion glycoprotein of the sea urchin embryo is an ironless, calcium-binding member of the transferrin family. Dev. Biol. 310, 54-70.

Alcedo, J., and Kenyon, C. (2004). Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 41, 45-55. (Cover; Featured and previewed article)

Alcedo, J.*, Zou, Y.*, and Noll, M. (2000). Posttranscriptional regulation of Smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol. Cell  6, 457-465. (*These authors contributed equally to this work.)

Alcedo, J., and Noll, M.  (1997). Hedgehog and its Patched-Smoothened receptor complex: a novel signalling mechanism at the cell surface. Biol. Chem.  378, 583-590. (Review; Cover)


​Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M., and Hooper, J. E.  (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell  86, 221-232.

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