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Sensory mechanisms that influence animal physiology and longevity​

For optimal survival, an animal has to process complex environmental information to generate the appropriate physiological responses. However, the mechanisms through which animals process complex information remain unknown. Recently, we have identified different neuropeptide signaling pathways that are involved in processing distinct sensory cues to promote different physiological outputs: (i) the neuromedin U signaling pathway in mediating the food-type influence on development and lifespan and (ii) specific insulin-like peptides in promoting distinct developmental switches under certain environments. In the future, we plan to elucidate how these neuropeptides encode and process environmental information to manage different physiological outputs, e.g., development versus lifespan.

Here's our newest publication:

Mishra, S., Dabaja, M., Akhlaq, A., Pereira, B., Marbach, K. Rovcanin, M., Chandra, R., Caballero, A., Fernandes de Abreu, D., Ch'ng, Q, and Alcedo, J. (2023). Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans. eLife 12, e83224. doi:

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Mohamed with Whitmer.jpg

Mohamed and other students met with Governor Whitmer during her visit to Wayne State on Mon, Mar 13, 2023

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